APP fibrils, Rabbit, Biotin, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody against amyloid fibrils and fibrillar oligomers.

Supplier:  Abnova Corporation PAB28921

Catalog No. 89-130-448

Description

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq

Specifications

• Antigen: APP fibrils
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody against amyloid fibrils and fibrillar oligomers.
• Formulation: PBS pH 7.4, 50% glycerol and 0.09% sodium azide
• Gene Accession No.: P05067
• Gene Symbols: APP
• Immunogen: Fibrils prepared from human Abeta42 peptide.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Test Specificity: PAB28921 recognizes generic epitopes common to many amyloid fibrils and fibrillar oligomers, but not prefibrilllar oligomers or natively folded proteins. 1:1000 dilution of PAB28921 was sufficient for detection of amyloid oligomers in 10ug of mouse brain lysates by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
• Content And Storage: Store at 4°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: Dot Blot, ELISA, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
• Conjugate: Biotin
• Dilution: Dot blot (1:1000) ELISA Immunocytochemistry Immunohistochemistry Immunoprecipitation Western Blot The optimal working dilution should be determined by the end user.
• Gene: APP
• Gene Alias: AAA/ABETA/ABPP/AD1/APPI/CTFgamma/CVAP/PN2
• Host Species: Rabbit
• Purification Method: Protein A affinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 351
• Target Species: Human, Mouse, Rat
• Form: Liquid

For Research Use Only