APP fibrils, Rabbit, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-130-437	100 μL

Catalog No. 89-130-437 Supplier Abnova Corporation Supplier No. PAB28910

Description

Rabbit polyclonal antibody against amyloid fibrils and fibrillar oligomers.

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq

Specifications

• Antigen: APP fibrils
• Applications: Dot Blot, ELISA, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody against amyloid fibrils and fibrillar oligomers.
• Dilution: Dot blot (1:1000) ELISA Immunocytochemistry Immunohistochemistry Immunoprecipitation Western Blot The optimal working dilution should be determined by the end user.
• Formulation: PBS pH 7.4, 50% glycerol and 0.09% sodium azide
• Gene: APP
• Gene Accession No.: P05067
• Gene Alias: AAA/ABETA/ABPP/AD1/APPI/CTFgamma/CVAP/PN2
• Gene Symbols: APP
• Host Species: Rabbit
• Immunogen: Fibrils prepared from human Abeta42 peptide.
• Purification Method: Protein A affinity purification
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 351
• Test Specificity: PAB28910 recognizes generic epitopes common to many amyloid fibrils and fibrillar oligomers, but not prefibrilllar oligomers or natively folded proteins. 1:1000 dilution of PAB28910 was sufficient for detection of amyloid oligomers in 10ug of mouse brain lysates by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only