APP oligomers, Rabbit, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody against amyloid oligomers.

Supplier:  Abnova Corporation PAB28928

Catalog No. 89-130-455

Description

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq

Specifications

• Antigen: APP oligomers
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody against amyloid oligomers.
• Formulation: PBS pH 7.4, 50% glycerol and 0.09% sodium azide
• Gene Alias: AAA/ABETA/ABPP/AD1/APPI/CTFgamma/CVAP/PN2
• Host Species: Rabbit
• Purification Method: Protein A affinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 351
• Target Species: Human, Mouse, Rat
• Form: Liquid

• Applications: Dot Blot, ELISA, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Dilution: Dot blot ELISA Immunofluorescence Immunohistochemistry (1:1000-10000) Immunoprecipitation (1:1000) Western Blot The optimal working dilution should be determined by the end user.
• Gene: APP
• Gene Symbols: APP
• Immunogen: Synthetic molecular mimic of soluble APP oligomers.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Test Specificity: PAB28928 recognizes all types of amyloid oligomers, likely with a peptide backbone epitope that is common in amyloid oligomers but not in native proteins, amyloidogenic monomer or mature amyloid fibrils. A 1:1000 dilution of PAB28928 was sufficient for detection of amyloid oligomers in 10ug of mouse brain lysates by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

For Research Use Only