AR Rabbit anti-Human, Polyclonal Antibody, Abnova
Rabbit polyclonal antibody raised against synthetic peptide of AR.
Manufacturer: Abnova Corporation PAB18448
The androgen receptor gene is more than 90kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq
|Rabbit polyclonal antibody raised against synthetic peptide of AR.|
|In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)|
|ELISA, Immunohistochemistry (PFA fixed)|
|Immunohistochemistry (1:50-1:100) ELISA (1:64000) The optimal working dilution should be determined by the end user.|
|A synthetic peptide corresponding to residues surrounding S213 of human AR.|
|Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
|This antibody is specific to AR.|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok
For Research Use Only