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AR Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of AR.

Manufacturer:  Abnova Corporation PAB18449

Catalog No. 89-120-012


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Description

Description

The androgen receptor gene is more than 90kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq

Specifications

Specifications

AR
1 mg/mL
Rabbit polyclonal antibody raised against synthetic peptide of AR.
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
P10275
AIS|DHTR|HUMARA|KD|NR3C4|SBMA|SMAX1|TFM
Rabbit
Affinity purification
RUO
Primary
367
Human
ELISA, Immunohistochemistry, Western Blot
Unconjugated
Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:100) ELISA (1:40000) The optimal working dilution should be determined by the end user.
AR
Liquid
AR
A synthetic peptide corresponding to residues surrounding S650 of human AR.
100 ug
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Polyclonal
This antibody is specific to AR.
SDS
Documents
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