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Description
This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq
Specifications
Specifications
| Antigen | ARNT2 |
| Applications | ELISA, Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Description | Rabbit polyclonal antibody raised against synthetic peptide of ARNT2. |
| Dilution | Western Blot (1:500-1:1000) ELISA (1:20000) The optimal working dilution should be determined by the end user. |
| Formulation | In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol) |
| Gene | ARNT2 |
| Gene Accession No. | Q9HBZ2 |
| Gene Alias | KIAA0307/bHLHe1 |
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