MilliporeSigma™ Rabbit anti-Arpin, Polyclonal,

Catalog No.	Quantity
ABT251MI	100 μL

Catalog No. ABT251MI Supplier MilliporeSigma™ Supplier No. ABT251

Description

Rabbit Polyclonal Antibody

Specifically detects Arpin in Human, Mouse samples, and it is validated for Immunocytochemistry, Western Blotting

Arpin (UniProt Q7Z6K5; also known as Arp2/3 inhibition protein, UPF0552 protein C15orf38) is encoded by the ARPIN (also known as C15orf38) gene (Gene ID 348110) in human. Cell migration requires the generation of branched actin networks that power the protrusion of the plasma membrane in lamellipodia. The actin-related proteins 2 and 3 (Arp2/3) complex nucleates actin filaments by binding to the side of an existing filament and initiating branch formation. Arpin functions as a negative regulator of Arp2/3 activity, allowing cells to control directional persistence of migration by fine-tuning actin nucleation activity at the leading edge of the lamellipodium. Arpin depletion in both mammalian cells and Dictyostelium discoideum amoeba is reported to result in straighter trajectories. Arpin microinjection is demonstrated to induce fish keratocytes to turn.

Specifications

• Antigen: Arpin
• Applications: Immunocytochemistry, Western Blot
• Classification: Polyclonal
• Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Accession No.: Q7Z6K5
• Gene Symbols: ARPIN; C15orf38
• Host Species: Rabbit
• Immunogen: KLH-conjugated linear peptide corresponding to human Arpin near the C-terminus.
• Purification Method: Affinity Purified
• Quantity: 100 μL
• Regulatory Status: RUO
• Research Discipline: Cell Structure
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_872422
• Target Species: Human, Mouse
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.

For Research Use Only