ATM Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova
Rabbit polyclonal antibody raised against synthetic peptide of ATM.
Manufacturer: Abnova Corporation PAB18452
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
|Rabbit polyclonal antibody raised against synthetic peptide of ATM.|
|In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)|
|ELISA, Immunohistochemistry (PFA fixed)|
|Immunohistochemistry (1:50-1:100) ELISA (1:64000) The optimal working dilution should be determined by the end user.|
|A synthetic peptide corresponding to residues surrounding S1981 of human ATM.|
|Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
|This antibody is specific to ATM.|
For Research Use Only