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Description
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c″, and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing. [provided by RefSeq]
Specifications
Specifications
| Antigen | ATP6V0A4 |
| Applications | ELISA, Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Description | Rabbit polyclonal antibody raised against synthetic peptide of ATP6V0A4. |
| Dilution | The optimal working dilution should be determined by the end user. |
| Formulation | In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide) |
| Gene | ATP6V0A4 |
| Gene Alias | A4/ATP6N1B/ATP6N2/MGC130016/MGC130017/RDRTA2/RTA1C/RTADR/STV1/VPH1/VPP2 |
| Gene Symbols | ATP6V0A4 |
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