BAI1 Rabbit anti-Bovine, Human, Monkey, Mouse, Polyclonal Antibody, Abnova
Rabbit polyclonal antibody raised against synthetic peptide of BAI1.
Manufacturer: Abnova Corporation PAB16409
Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq
|Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (20 ug/mL) The optimal working dilution should be determined by the end user.|
|A synthetic peptide (conjugated with KLH) corresponding to human BAI1.|
|Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.
|N-terminal domain of human.|
|Immunohistochemistry (PFA fixed)|
|Rabbit polyclonal antibody raised against synthetic peptide of BAI1.|
|In PBS (0.09% sodium azide)|
|Bovine, Human, Monkey, Murine|
For Research Use Only