MilliporeSigma™ Rabbit anti-Bcl-B, Polyclonal,

Catalog No.	Quantity
ABC1484MI	100 μg

Catalog No. ABC1484MI Supplier MilliporeSigma™ Supplier No. ABC1484

Description

Rabbit Polyclonal Antibody

Specifically detects Bcl-B in Human samples, and it is validated for Immunocytochemistry, Western Blotting

The protein named Bcl-2-like protein 10 (Bcl2-L-10) or alternatively Anti-apoptotic protein NrH or Apoptosis regulator Bcl-B, and encoded by the human gene BCL2L10/BCLB is member of the BcL2 anti-apoptosis family and promotes cell survival by suppressing the actions of BAX and BAK in destabilizing the mitochondrial membrane potential leading to apoptosis activation. Bcl-B can interact with Bcl-2, BcL2L1/BCL-XL, and BAX. It is expressed in the cytoplasm and interacts primarily at the mitochondrial membranes. Bcl-B is abundantly expressed in human embryos prior to implantation and was predominantly cytoplasmic with localization at the mitochondria in normal embryos. In abnormal embryos Bcl-B was outside the mitochondria as well as nuclear located, but the exact nature of the role of Bcl-B in abnormal embryos is still be elucidated. Interestingly, Bcl-B because of its anti-apoptotic effects is also the cause for anti-cancer drug resistance and it is used a marker for potential drug failures in anti-cancer therapy.

Specifications

• Antigen: Bcl-B
• Applications: Immunocytochemistry, Western Blot
• Classification: Polyclonal
• Formulation: Purified rabbit polyclonal in buffer containing PBS (pH 7.2) with 0.02% sodium azide.
• Gene Accession No.: Q9HD36
• Gene Symbols: BCL2L10; BCLB
• Host Species: Rabbit
• Immunogen: Bcl-B antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human Bcl-B.
• Purification Method: Affinity Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Apoptosis, Cancer
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.

For Research Use Only