BCL2L1 Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of BCL2L1.

Manufacturer:  Abnova Corporation PAB18270

Catalog No. 89-119-840

Description

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq

Specifications

• Antigen: BCL2L1
• Concentration: 1 mg/mL
• Description: Rabbit polyclonal antibody raised against synthetic peptide of BCL2L1.
• Formulation: In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
• Gene Accession No.: Q07817
• Gene Alias: BCL-XL/S|BCL2L|BCLX|Bcl-X|DKFZp781P2092|bcl-xL|bcl-xS
• Host Species: Rabbit
• Purification Method: Affinity purification
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 598
• Target Species: Human, Murine, Rat

• Applications: ELISA, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
• Conjugate: Unconjugated
• Dilution: Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:100) Immunofluorescence (1:500-1:1000) ELISA (1:5000) The optimal working dilution should be determined by the end user.
• Gene: BCL2L1
• Format: Liquid
• Gene Symbols: BCL2L1
• Immunogen: A synthetic peptide corresponding to residues surrounding T47 of human BCL2L1.
• Quantity: 100 ug
• Storage Requirements: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Monoclonal or Polyclonal: Polyclonal
• Test Specificity: This antibody is specific to BCL2L1.

For Research Use Only