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Description
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq
Specifications
Specifications
| Antigen | BCL2L10 |
| Applications | Immunocytochemistry, Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Description | Rabbit polyclonal antibody raised against synthetic peptide of BCL2L10. |
| Dilution | Western Blot (1-2 ug/mL) The optimal working dilution should be determined by the end user. |
| Formulation | In PBS (0.02% sodium azide) |
| Gene | BCL2L10 |
| Gene Accession No. | NP_065129 |
| Gene Alias | BCL-B/Boo/Diva/MGC129810/MGC129811 |
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