BCL2L11 Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-128-959	100 μg

Catalog No. 89-128-959 Supplier Abnova Corporation Supplier No. PAB27448

Description

Rabbit polyclonal antibody raised against synthetic peptide of BCL2L11.

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq

Specifications

• Antigen: BCL2L11
• Applications: ELISA, Immunocytochemistry, Immunofluorescence, Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of BCL2L11.
• Dilution: Western Blot (1-2 ug/mL) Immunocytochemistry (2.5 ug/mL) Immunofluorescence (2.5 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.02% sodium azide)
• Gene: BCL2L11
• Gene Accession No.: NP_619527
• Gene Alias: BAM/BIM/BIM-alpha6/BIM-beta6/BIM-beta7/BOD/BimEL/BimL
• Gene Symbols: BCL2L11
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to 15 amino acids at N-terminus of human BCL2L11.
• Purification Method: Peptide affinity purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10018
• Test Specificity: BCL2L11 antibody is human and mouse reactive. Multiple isoforms of Bim are known to exist; this antibody only detects the BCL2L11 isoform.
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C for three months. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG

For Research Use Only