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Description
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq
Specifications
Specifications
| Antigen | BCL6 |
| Applications | Immunohistochemistry (PFA fixed) |
| Classification | Polyclonal |
| Concentration | Lot specific |
| Conjugate | Unconjugated |
| Description | Rabbit polyclonal antibody raised against synthetic peptide of BCL6. |
| Dilution | Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (Formalin/PFA-fixed paraffin-embedded sections) (1:50) The optimal working dilution should be determined by the end user. |
| Formulation | In 10mM PBS, pH 7.4 (1% BSA, 0.09% sodium azide) |
| Gene | BCL6 |
| Gene Alias | BCL5/BCL6A/LAZ3/ZBTB27/ZNF51 |
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