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BCR Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of BCR.

Supplier:  Abnova Corporation PAB18271

Catalog No. 89-119-841


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Description

Description

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Specifications

Specifications

BCR
Polyclonal
Unconjugated
Immunohistochemistry (1:50-1:100) ELISA (1:5000) The optimal working dilution should be determined by the end user.
BCR
ALL/BCR-ABL1/BCR1/CML/D22S11/D22S662/FLJ16453/PHL
Rabbit
Affinity purification
RUO
613
Human, Mouse
Liquid
ELISA, Immunohistochemistry (PFA fixed)
1 mg/mL
Rabbit polyclonal antibody raised against synthetic peptide of BCR.
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
P11274
BCR
A synthetic peptide corresponding to human BCR.
100 μg
Primary
This antibody is specific to BCR.
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
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