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BCR Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova™
Rabbit polyclonal antibody raised against synthetic peptide of BCR.
Supplier: Abnova Corporation PAB18271
Description
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Specifications
BCR | |
Polyclonal | |
Unconjugated | |
Immunohistochemistry (1:50-1:100) ELISA (1:5000) The optimal working dilution should be determined by the end user. | |
BCR | |
ALL/BCR-ABL1/BCR1/CML/D22S11/D22S662/FLJ16453/PHL | |
Rabbit | |
Affinity purification | |
RUO | |
613 | |
Human, Mouse | |
Liquid |
ELISA, Immunohistochemistry (PFA fixed) | |
1 mg/mL | |
Rabbit polyclonal antibody raised against synthetic peptide of BCR. | |
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide) | |
P11274 | |
BCR | |
A synthetic peptide corresponding to human BCR. | |
100 μg | |
Primary | |
This antibody is specific to BCR. | |
Store at -20°C. Aliquot to avoid repeated freezing and thawing. |
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For Research Use Only