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Description
BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]).[supplied by OMIM
Specifications
Specifications
| Antigen | BEST3 |
| Applications | Immunohistochemistry (PFA fixed) |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Description | Rabbit polyclonal antibody raised against synthetic peptide of BEST3. |
| Dilution | Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5-7.5 ug/mL) The optimal working dilution should be determined by the end user. |
| Formulation | In PBS (0.09% sodium azide) |
| Gene | BEST3 |
| Gene Accession No. | Q8N1M1 |
| Gene Alias | MGC13168/MGC40411/VMD2L3 |
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