MilliporeSigma™ Rabbit anti-Biglycan, Polyclonal,

Catalog No.	Quantity
ABT271MI	100 μL

Catalog No. ABT271MI Supplier MilliporeSigma™ Supplier No. ABT271

Description

Rabbit Polyclonal Antibody

Specifically detects Biglycan in Human samples, and it is validated for Immunohistochemistry, Western Blotting

Biglycan (UniProt P21810; also known as Biglycan proteoglycan, Bone/cartilage proteoglycan I, Dermatan sulphate proteoglycan I, PG-S1, Small leucine-rich protein 1A) is encoded by the BGN (also known as DSPG1, PGI, SLRR1A) gene (Entrez Gene ID 633) in human. Biglycan is a pericellular matrix proteoglycan structurally related to two other small proteoglycans, decorin and fibromodulin. Biglycan and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while biglycan contains two chains, and therefore the name biglycan. Biglycan is involved in collagen fibrils assembly and muscle regeneration. Biglycan is essential for the assembly of dystrophin-associated protein complex, and interacts with several proteins linked to muscular dystrophy, including alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI. Biglycan is initially translated as a preproprotein with an N-terminal signal peptide (aa1-19) and propeptide (aa20-37) sequence. Sequential removal of the signal peptide and the propeptide sequence produces probiglycan and mature biglycan, respectively.

Specifications

• Antigen: Biglycan
• Applications: Immunohistochemistry, Western Blot
• Classification: Polyclonal
• Formulation: Rabbit polyclonal antibody serum with 0.05% sodium azide.
• Gene Accession No.: P21810
• Gene Symbols: BGN; SLRR1A
• Host Species: Rabbit
• Immunogen: BSA-conjugated linear peptide corresponding to the mature chain of human Biglycan.
• Purification Method: Unpurified
• Quantity: 100 μL
• Regulatory Status: RUO
• Research Discipline: Cell Structure
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_001702
• Target Species: Human
• Content And Storage: Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
• Form: Serum

For Research Use Only