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BRAF (phospho S446), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Catalog No. 89133486 Shop All Abnova Corporation Products
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89-133-486 100 μL
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Catalog No. 89-133-486 Supplier Abnova Corporation Supplier No. PAB7907
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Description

Rabbit polyclonal antibody raised against synthetic phosphopeptide of BRAF .

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, nonsmall cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq

Specifications

Antigen BRAF
Applications ELISA, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic phosphopeptide of BRAF .
Dilution ELISA (1:2000) Western Blot (1:500) The optimal working dilution should be determined by the end user.
Formulation In PBS (50% glycerol, 1mg/mL BSA, 0.05% sodium azide)
Gene BRAF
Gene Alias B-RAF1/BRAF1/FLJ95109/MGC126806/MGC138284/RAFB1
Gene Symbols BRAF
Host Species Rabbit
Immunogen Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S446 of human BRAF .
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 673
Test Specificity This sequence is conserved in B-Rafs from many species, and has high homology to C-Raf (Ser-338) and A-Raf (Ser-299).
Target Species Human, Mouse, Rat
Content And Storage Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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