CASP3 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-127-281	100 μg

Catalog No. 89-127-281 Supplier Abnova Corporation Supplier No. PAB25662

Description

Rabbit polyclonal antibody raised against synthetic peptide of CASP3.

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq]

Specifications

• Antigen: CASP3
• Applications: ELISA, Immunohistochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of CASP3.
• Dilution: Immunohistochemistry (5 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.05% sodium azide)
• Gene: CASP3
• Gene Accession No.: NP_004337
• Gene Alias: CPP32/CPP32B/SCA-1
• Gene Symbols: CASP3
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to 17 amino acids at internal region of human CASP3.
• Purification Method: Peptide affinity purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 836
• Test Specificity: At least two isoforms of Caspase-3 are known to exist.
• Target Species: Human
• Content And Storage: Store at 4°C for three months. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG

For Research Use Only