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CASP8 Rabbit anti-Gerbils, Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Catalog No. 89114070 Shop All Abnova Corporation Products
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89-114-070 50 μL
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Catalog No. 89-114-070 Supplier Abnova Corporation Supplier No. PAB0247
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Description

Rabbit polyclonal antibody raised against synthetic peptide of CASP8.

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq

Sequence: PQPTFTLRKKLVFPSD

Specifications

Antigen CASP8
Applications Immunohistochemistry (Frozen), Immunohistochemistry (PFA fixed), Immunoprecipitation
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of CASP8.
Dilution The optimal working dilution should be determined by the end user.
Formulation In serum (0.05% sodium azide)
Gene CASP8
Gene Alias ALPS2B/CAP4/FLICE/FLJ17672/MACH/MCH5/MGC78473
Gene Symbols CASP8
Host Species Rabbit
Immunogen A synthetic peptide corresponding to human CASP8.
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 841
Target Species Gerbil, Human, Mouse, Rat
Content And Storage Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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