CASP8 Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-116-387	100 μg

Catalog No. 89-116-387 Supplier Abnova Corporation Supplier No. PAB13140

Description

Rabbit polyclonal antibody raised against synthetic peptide of CASP8.

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq

Specifications

• Antigen: CASP8
• Applications: Immunocytochemistry, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of CASP8.
• Dilution: Western Blot (0.5 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.02% sodium azide)
• Gene: CASP8
• Gene Accession No.: NP_001219
• Gene Alias: ALPS2B/CAP4/FLICE/FLJ17672/MACH/MCH5/MGC78473
• Gene Symbols: CASP8
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to C-terminus 16 amino acids of human CASP8.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 841
• Test Specificity: Depending on cell lines or tissues used, either full-length or other cleavage products may be observed.
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C for three months. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only