CASP8 Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-116-797	100 μg

Catalog No. 89-116-797 Supplier Abnova Corporation Supplier No. PAB13681

Description

Rabbit polyclonal antibody raised against synthetic peptide of CASP8.

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq

Specifications

• Antigen: CASP8
• Applications: Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of CASP8.
• Dilution: Western Blot (1 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: Lyophilized from 0.9mg NaCl, 0.2mg Na₂HPO₄ (5mg BSA, 0.05mg sodium azide, 0.05mg Thimerosal)
• Gene: CASP8
• Gene Alias: ALPS2B/CAP4/FLICE/FLJ17672/MACH/MCH5/MGC78473
• Gene Symbols: CASP8
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to amino acids at internal region of human CASP8.
• Purification Method: Affinity purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 841
• Test Specificity: Different to the related mouse sequence by a single amino acids.
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at -20°C on dry atmosphere. After reconstitution with 200μL of deionized water and concentration will be 500μ/mL store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Form: Lyophilized
• Isotype: IgG

For Research Use Only