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CASP8 Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of CASP8.

Manufacturer:  Abnova Corporation PAB13681

Catalog No. 89-116-797


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Description

Description

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq

Specifications

Specifications

CASP8
Unconjugated
Western Blot (1 ug/mL) The optimal working dilution should be determined by the end user.
CASP8
ALPS2B|CAP4|FLICE|FLJ17672|MACH|MCH5|MGC78473
Rabbit
IgG
100 ug
Store at -20°C on dry atmosphere. After reconstitution with 200μL of deionized water and concentration will be 500μ/mL
Polyclonal
Different to the related mouse sequence by a single amino acids.
Western Blot
Rabbit polyclonal antibody raised against synthetic peptide of CASP8.
Lyophilized from 0.9mg NaCl, 0.2mg Na2HPO4 (5mg BSA, 0.05mg sodium azide, 0.05mg Thimerosal)
Lyophilized
CASP8
A synthetic peptide corresponding to amino acids at internal region of human CASP8.
Affinity purification
RUO
Primary
841
Human, Murine, Rat
SDS
Documents
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