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CCND1 Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of CCND1.

Manufacturer:  Abnova Corporation PAB18149

Catalog No. 89-119-722


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Description

Description

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq

Specifications

Specifications

CCND1
1 mg/mL
Rabbit polyclonal antibody raised against synthetic peptide of CCND1.
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
P24385
BCL1|D11S287E|PRAD1|U21B31
Rabbit
Affinity purification
RUO
Primary
595
Human, Murine, Rat
ELISA, Immunohistochemistry (PFA fixed), Western Blot
Unconjugated
Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:100) ELISA (1:40000) The optimal working dilution should be determined by the end user.
CCND1
Liquid
CCND1
A synthetic peptide corresponding to human CCND1.
100 ug
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Polyclonal
This antibody is specific to CCND1.
SDS
Documents
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