CCND1 Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova
Rabbit polyclonal antibody raised against synthetic peptide of CCND1.
Manufacturer: Abnova Corporation PAB18149
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq
|Rabbit polyclonal antibody raised against synthetic peptide of CCND1.|
|In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)|
|Human, Murine, Rat|
|ELISA, Immunohistochemistry (PFA fixed), Western Blot|
|Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:100) ELISA (1:40000) The optimal working dilution should be determined by the end user.|
|A synthetic peptide corresponding to human CCND1.|
|Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
|This antibody is specific to CCND1.|
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