CCND1 Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-127-016	400 μL

Catalog No. 89-127-016 Supplier Abnova Corporation Supplier No. PAB2538

Description

Rabbit polyclonal antibody raised against synthetic peptide of CCND1.

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq

Specifications

• Antigen: CCND1
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of CCND1.
• Dilution: Western Blot (1:1000) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.09% sodium azide)
• Gene: CCND1
• Gene Accession No.: NP_444284;Q6FI00
• Gene Alias: BCL1/D11S287E/PRAD1/U21B31
• Gene Symbols: CCND1
• Host Species: Rabbit
• Immunogen: A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human CCND1.
• Purification Method: Ammonium sulfate precipitation
• Quantity: 400 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 595
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only