CCNE1 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-119-809	100 μg

Catalog No. 89-119-809 Supplier Abnova Corporation Supplier No. PAB18239

Description

Rabbit polyclonal antibody raised against synthetic peptide of CCNE1.

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq

Specifications

• Antigen: CCNE1
• Applications: ELISA, Immunofluorescence, Immunohistochemistry (PFA fixed)
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of CCNE1.
• Dilution: Immunohistochemistry (1:50-1:100) Immunofluorescence (1:500-1:1000) ELISA (1:10000) The optimal working dilution should be determined by the end user.
• Formulation: In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
• Gene: CCNE1
• Gene Accession No.: P24864
• Gene Alias: CCNE
• Gene Symbols: CCNE1
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to human CCNE1.
• Purification Method: Affinity purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 898
• Test Specificity: This antibody is specific to CCNE1.
• Target Species: Human
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only