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CCR10 Rabbit anti-Human, Polyclonal Antibody, Abnova
Rabbit polyclonal antibody raised against synthetic peptide of CCR10.
Manufacturer: Abnova Corporation PAB26080
Chemokines are a group of small (approximately 8 to 14kDa), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM
|Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (3-4 ug/mL) The optimal working dilution should be determined by the end user.|
|A synthetic peptide corresponding to 19 amino acids at C-terminus of human CCR10.|
|Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.
|BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Immunohistochemistry (PFA fixed)|
|Rabbit polyclonal antibody raised against synthetic peptide of CCR10.|
|In PBS (0.09% sodium azide)|
For Research Use Only