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CD40 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No. 89114942 Shop All Abnova Corporation Products
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100 μL
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89-114-942 100 μL
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Catalog No. 89-114-942 Supplier Abnova Corporation Supplier No. PAB11229

Description

Rabbit polyclonal antibody raised against synthetic peptide of CD40.

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq

Specifications

Antigen CD40
Applications Immunohistochemistry (PFA fixed)
Classification Polyclonal
Concentration Lot specific
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of CD40.
Dilution Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (Formalin/PFA-fixed paraffin-embedded sections) (1:100) The optimal working dilution should be determined by the end user.
Formulation In 10mM PBS, pH 7.4 (1% BSA, 0.09% sodium azide)
Gene CD40
Gene Alias Bp50/CDW40/MGC9013/TNFRSF5/p50
Gene Symbols CD40
Host Species Rabbit
Immunogen A synthetic peptide corresponding to C-terminus of human CD40.
Purification Method Immunoaffinity purification
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 958
Target Species Human
Content And Storage Store at 4°C.
Form Liquid
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