CD40 Rabbit anti-Dog, Gerbils, Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against a recombinant CD40.

Supplier:  Abnova Corporation PAB0251

Catalog No. 89-114-074

Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq

Specifications

• Antigen: CD40
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against a recombinant CD40.
• Formulation: In serum (0.05% sodium azide)
• Gene Alias: Bp50/CDW40/MGC9013/TNFRSF5/p50
• Host Species: Rabbit
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Canine, Gerbil, Human, Mouse, Rat
• Form: Liquid

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (PFA fixed), Immunoprecipitation
• Conjugate: Unconjugated
• Dilution: The optimal working dilution should be determined by the end user.
• Gene: CD40
• Gene Symbols: CD40
• Immunogen: Recombinant protein corresponding to short cytoplasmic region of the human CD40.
• Regulatory Status: RUO
• Gene ID (Entrez): 958
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

For Research Use Only