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CD40 Rabbit anti-Dog, Gerbils, Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Catalog No. 89114074 Shop All Abnova Corporation Products
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89-114-074 50 μL
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Catalog No. 89-114-074 Supplier Abnova Corporation Supplier No. PAB0251
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Description

Rabbit polyclonal antibody raised against a recombinant CD40.

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq

Specifications

Antigen CD40
Applications Immunohistochemistry (Frozen), Immunohistochemistry (PFA fixed), Immunoprecipitation
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against a recombinant CD40.
Dilution The optimal working dilution should be determined by the end user.
Formulation In serum (0.05% sodium azide)
Gene CD40
Gene Alias Bp50/CDW40/MGC9013/TNFRSF5/p50
Gene Symbols CD40
Host Species Rabbit
Immunogen Recombinant protein corresponding to short cytoplasmic region of the human CD40.
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 958
Target Species Canine, Gerbil, Human, Mouse, Rat
Content And Storage Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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