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Description
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. [provided by RefSeq
Specifications
Specifications
| Antigen | CDH4 |
| Applications | ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Description | Rabbit polyclonal antibody raised against synthetic peptide of CDH4. |
| Dilution | Western Blot (1:1000) Immunohistochemistry (1:10-50) Immunofluorescence (1:10-50) Flow cytometry (1:10-50) The optimal working dilution should be determined by the end user. |
| Formulation | In PBS (0.09% sodium azide) |
| Gene | CDH4 |
| Gene Accession No. | NP_001785;P55283 |
| Gene Alias | CAD4/FLJ22202/FLJ40547/MGC126700/MGC138355/RCAD |
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