CDKN2A Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-120-415	100 μg

Catalog No. 89-120-415 Supplier Abnova Corporation Supplier No. PAB18855

Description

Rabbit polyclonal antibody raised against synthetic peptide of CDKN2A.

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq

Specifications

• Antigen: CDKN2A
• Applications: ELISA, Immunohistochemistry (PFA fixed)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of CDKN2A.
• Dilution: ELISA (1:10000-1:40000) Immunohistochemistry (1:50-1:200) The optimal working dilution should be determined by the end user.
• Formulation: In buffer containing 0.02% sodium azide, 2% BSA
• Gene: CDKN2A
• Gene Accession No.: NM_000077
• Gene Alias: ARF/CDK4I/CDKN2/CMM2/INK4/INK4a/MLM/MTS1/TP16/p14/p14ARF/p16/p16INK4/p16INK4a/p19
• Gene Symbols: CDKN2A
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to amino acids of C-terminus of human CDKN2A.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1029
• Target Species: Human
• Content And Storage: Store at 4°C for three months. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only