CDKN2A (phospho S152), Rabbit, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-114-271	400 μL

Catalog No. 89-114-271 Supplier Abnova Corporation Supplier No. PAB0553

Description

Rabbit polyclonal antibody raised against synthetic phosphopeptide of CDKN2A.

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq

Specifications

• Antigen: CDKN2A
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
• Formulation: In PBS (0.09% sodium azide)
• Gene: CDKN2A
• Gene Accession No.: NP_000068;P42771
• Gene Alias: ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, TP16, p14, p14ARF, p16, p16INK4, p16INK4a, p19
• Gene Symbols: CDKN2A
• Host Species: Rabbit
• Immunogen: Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S152 of human CDKN2A.
• Purification Method: Protein G purification
• Quantity: 400 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1029
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing.
• Form: Purified

For Research Use Only