CIITA Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-134-513	100 μL

Catalog No. 89-134-513 Supplier Abnova Corporation Supplier No. PAB9942

Description

Rabbit polyclonal antibody raised against partial recombinant CIITA.

This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the master control factor for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq]

Specifications

• Antigen: CIITA
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against partial recombinant CIITA.
• Dilution: Western Blot (1:500) The optimal working dilution should be determined by the end user.
• Formulation: In antiserum (0.01% sodium azide)
• Gene: CIITA
• Gene Alias: C2TA/CIITAIV/MHC2TA/NLRA
• Gene Symbols: CIITA
• Host Species: Rabbit
• Immunogen: Recombinant Flag fusion protein corresponding to amino acids 1-333 of human CIITA.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4261
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only