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COMT Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No. 89129345 Shop All Abnova Corporation Products
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50 μg
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89-129-345 50 μg
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Catalog No. 89-129-345 Supplier Abnova Corporation Supplier No. PAB27823
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Description

Rabbit polyclonal antibody raised against synthetic peptide of COMT.

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq

Specifications

Antigen COMT
Applications Immunohistochemistry (PFA fixed)
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of COMT.
Dilution Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2.5 ug/mL) The optimal working dilution should be determined by the end user.
Formulation In PBS (0.09% sodium azide)
Gene COMT
Gene Accession No. P21964
Gene Symbols COMT
Host Species Rabbit
Immunogen A synthetic peptide corresponding to 19 amino acid at internal region of human COMT.
Purification Method Immunoaffinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1312
Test Specificity BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Target Species Human
Content And Storage Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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