MilliporeSigma™ Rabbit anti-COUP-TF2, Polyclonal,

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ ABE1426

Catalog No. ABE1426MI

Description

Specifically detects COUP-TF2 in Human, Mouse samples, and it is validated for ChIP, Immunofluorescence, Immunohistochemistry, Western Blotting

COUP transcription factor 2 (UniProt P43135; also known as Apolipoprotein AI regulatory protein 1, Apolipoprotein regulatory protein 1, ARP-1, COUP-TF II, COUP transcription factor II, Nuclear receptor subfamily 2 group F member 2) is encoded by the Nr2f2 (also known as Aporp1, Arp-1, Arp1, Tfcoup2) gene (Gene ID 11819) in murine species. COUP transcription factors1&2 (COUP-TFI & COUP-TFII) are two related nuclear orphan receptors implicated in their roles in guiding migrating neurons towards their target regions during brain development. COUP-TFI and COUP-TFII are expressed in distinct and non-overlapping migrating cells in specific pathways in the basal telencephalon of mouse embryos at a stage when interneuron migration is robust. While COUP-TFI appears to control dorsal and ventral migration in the basal telencephalon, COUP-TFII is more specific in modulating tangential migration into the intermediate zone of the cortex. Coup-TFII is also identified as an activator of Prox1 expression in venous lymphatic endothelial cell (LEC) progenitors during early stages of LEC specification and differentiation.

Specifications

• Antigen: COUP-TF2
• Classification: Polyclonal
• Gene Accession No.: P43135
• Host Species: Rabbit
• Purification Method: Unpurified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Form: Serum

• Applications: ChIP Assay, Immunofluorescence, Immunohistochemistry, Western Blot
• Formulation: Rabbit polyclonal serum with 0.05% sodium azide.
• Gene Symbols: Nr2f2; Aporp1; Arp-1; Arp1; Tfcoup2
• Immunogen: GST-tagged recombinant protein corresponding to the the N-terminal half of mouse COUP-TF2.
• Quantity: 100 μL
• Research Discipline: Epigenetics and Nuclear Function
• Gene ID (Entrez): NP_033827
• Content And Storage: Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.

For Research Use Only