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CR1, Rabbit, Clone: SP191, Abnova™

Catalog No. 89110305 Shop All Abnova Corporation Products
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89-110-305 100 μL
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Catalog No. 89-110-305 Supplier Abnova Corporation Supplier No. MAB12164

Description

Rabbit monoclonal antibody raised against synthetic peptide of human CR1.

This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq]

Specifications

Antigen CR1
Applications Immunohistochemistry (PFA fixed)
Classification Monoclonal
Clone SP191
Conjugate Unconjugated
Description Rabbit monoclonal antibody raised against synthetic peptide of human CR1.
Dilution Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100) The optimal working dilution should be determined by the end user.
Formulation In 10mM PBS, pH 7.6 (1% BSA, 0.09% sodium azide)
Gene CR1
Gene Alias C3BR/CD35/KN
Gene Symbols CR1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to C-terminus region of human CR1.
Purification Method Protein A/G purification
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1378
Target Species Human
Content And Storage Store at 4°C.
Form Liquid
Isotype IgG
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