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Description
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. [provided by RefSeq
Specifications
Specifications
| Antigen | CSE1L |
| Applications | Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot |
| Classification | Polyclonal |
| Concentration | 1 mg/mL |
| Conjugate | Unconjugated |
| Description | Rabbit polyclonal antibody raised against synthetic peptide of CSE1L. |
| Dilution | Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:200) Immunoprecipitation (1:50-1:200) Immunofluorescence (1:50-1:200) The optimal working dilution should be determined by the end user. |
| Formulation | In PBS, pH 7.2 (0.05% sodium azide) |
| Gene | CSE1L |
| Gene Alias | CAS/CSE1/MGC117283/MGC130036/MGC130037/XPO2 |
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