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CXCR2 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No. 89127806 Shop All Abnova Corporation Products
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89-127-806 50 μg
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Catalog No. 89-127-806 Supplier Abnova Corporation Supplier No. PAB26166
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Description

Rabbit polyclonal antibody raised against synthetic peptide of CXCR2.

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq

Specifications

Antigen CXCR2
Applications Immunohistochemistry (PFA fixed)
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of CXCR2.
Dilution Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (7 ug/mL) The optimal working dilution should be determined by the end user.
Formulation In PBS (0.09% sodium azide)
Gene CXCR2
Gene Accession No. P25025
Gene Alias CD182/CDw128b/CMKAR2/IL8R2/IL8RA/IL8RB
Gene Symbols CXCR2
Host Species Rabbit
Immunogen A synthetic peptide corresponding to 16 amino acids at N-terminus of human CXCR2.
Purification Method Immunoaffinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3579
Test Specificity BLAST analysis of the peptide immunogen showed no homology with other human proteins, except EYA3 (50%).
Target Species Human
Content And Storage Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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