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MilliporeSigma™ Rabbit anti-Cytosolic 5'-nucleotidase II, Polyclonal,

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ABC481MI 100 μg
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Catalog No. ABC481MI Supplier MilliporeSigma™ Supplier No. ABC481
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Description

Rabbit Polyclonal Antibody

Specifically detects Cytosolic 5'-nucleotidase II in Human samples, and it is validated for Immunohistochemistry, Western Blotting

Cytosolic purine 5'-nucleotidase (EC 3.1.3.5; UniProt P49902; also known as 5'-nucleotidase (purine), cytosolic type B, Cytosolic 5'-nucleotidase II, IMP-specific 5'-NT, Purine 5' nucleotidase) is encoded by the NT5C2 (also known as cN-II, GMP, NT5B, NT5CP, PNT5, SPG45, SPG65) gene (Entrez Gene ID 22978) in human. NT5C2 protein is a cytosolic enzyme that catalyzes the hydrolysis of inosine 5'-monophosphate (IMP) and other purine nucleotides into the corresponding ribonucleoside and a phosphate. Purine nucleotides are neuroprotective and play a critical role in the ischemic and developing brain, alterations in purine nucleotides levels could sensitize neurons to stress and insult. Hereditary spastic paraplegias (HSPs) are neurodegenerative motor neuron diseases characterized by progressive age-dependent loss of corticospinal motor tract function. Mutations in NT5C2 and several other genes coding for purine nucleotide metabolizing enzymes are linked to autosomal recessive HSP (AR-HSP) in a study of 55 families displaying AR-HSP (PMID 24482476).
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cytosolic 5'-nucleotidase II
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Formulation Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. P49902
Gene Symbols NT5C2; NT5B; NT5CP; PNT5
Host Species Rabbit
Immunogen KLH-conjugated linear peptide corresponding to human Cytosolic 5'-nucleotidase II near the C-terminus.
Purification Method Affinity Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Apoptosis, Cancer
Primary or Secondary Primary
Gene ID (Entrez) NP_001127845
Target Species Human
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
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