MilliporeSigma™ Rabbit anti-Cytosolic 5'-nucleotidase II, Polyclonal,

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ ABC481

Catalog No. ABC481MI

Description

Specifically detects Cytosolic 5'-nucleotidase II in Human samples, and it is validated for Immunohistochemistry, Western Blotting

Cytosolic purine 5'-nucleotidase (EC 3.1.3.5; UniProt P49902; also known as 5'-nucleotidase (purine), cytosolic type B, Cytosolic 5'-nucleotidase II, IMP-specific 5'-NT, Purine 5' nucleotidase) is encoded by the NT5C2 (also known as cN-II, GMP, NT5B, NT5CP, PNT5, SPG45, SPG65) gene (Entrez Gene ID 22978) in human. NT5C2 protein is a cytosolic enzyme that catalyzes the hydrolysis of inosine 5'-monophosphate (IMP) and other purine nucleotides into the corresponding ribonucleoside and a phosphate. Purine nucleotides are neuroprotective and play a critical role in the ischemic and developing brain, alterations in purine nucleotides levels could sensitize neurons to stress and insult. Hereditary spastic paraplegias (HSPs) are neurodegenerative motor neuron diseases characterized by progressive age-dependent loss of corticospinal motor tract function. Mutations in NT5C2 and several other genes coding for purine nucleotide metabolizing enzymes are linked to autosomal recessive HSP (AR-HSP) in a study of 55 families displaying AR-HSP (PMID 24482476).

Specifications

• Antigen: Cytosolic 5'-nucleotidase II
• Classification: Polyclonal
• Gene Accession No.: P49902
• Host Species: Rabbit
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human

• Applications: Immunohistochemistry, Western Blot
• Formulation: Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Symbols: NT5C2; NT5B; NT5CP; PNT5
• Immunogen: KLH-conjugated linear peptide corresponding to human Cytosolic 5'-nucleotidase II near the C-terminus.
• Quantity: 100 μg
• Research Discipline: Apoptosis, Cancer
• Gene ID (Entrez): NP_001127845
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.

For Research Use Only