DDR1 (phospho Y513), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of human DDR1.

Supplier:  Abnova Corporation PAB29227

Catalog No. 89-130-662

Description

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq

Specifications

• Antigen: DDR1
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic phosphopeptide of human DDR1.
• Formulation: In PBS, pH 7.4 (without mg²⁺ and Ca²⁺), (50% glycerol, 0.02% sodium azide)
• Gene Accession No.: Q08345
• Gene Symbols: DDR1
• Immunogen: Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y513 of human DDR1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Test Specificity: This antibody detects endogenous levels of DDR1 only when phosphorylated at tyrosine 513.
• Content And Storage: Store at -20°C.
  Avoid repeated freezing and thawing.

• Applications: Immunohistochemistry (PFA fixed), Western Blot
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry (1:50-1:100) Western Blot (1:500-1000) The optimal working dilution should be determined by the end user.
• Gene: DDR1
• Gene Alias: CAK/CD167/DDR/EDDR1/MCK10/NEP/NTRK4/PTK3/PTK3A/RTK6/TRKE
• Host Species: Rabbit
• Purification Method: Affinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 780
• Target Species: Human, Mouse, Rat
• Form: Liquid

For Research Use Only