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DFFA Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No. 89115243 Shop All Abnova Corporation Products
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89-115-243 100 μL
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Catalog No. 89-115-243 Supplier Abnova Corporation Supplier No. PAB11637

Description

Rabbit polyclonal antibody raised against synthetic peptide of DFFA.

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40kDa (DFFB) and 45kDa (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq

Specifications

Antigen DFFA
Applications Immunohistochemistry (PFA fixed)
Classification Polyclonal
Concentration Lot specific
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of DFFA.
Dilution Western Blot (1:50) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (Formalin/PFA-fixed paraffin-embedded sections) (1:100) The optimal working dilution should be determined by the end user.
Formulation In 10mM PBS, pH 7.4 (1% BSA, 0.09% sodium azide)
Gene DFFA
Gene Alias DFF-45/DFF1/ICAD
Gene Symbols DFFA
Host Species Rabbit
Immunogen A synthetic peptide corresponding to N-terminus of human DFFA.
Purification Method Immunoaffinity purification
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1676
Target Species Human
Content And Storage Store at 4°C.
Form Liquid
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For Research Use Only

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