DFFB Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of DFFB.

Supplier:  Abnova Corporation PAB13403

Catalog No. 89-116-649

Description

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40kDa (DFFB) and 45kDa (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined. [provided by RefSeq

Specifications

• Antigen: DFFB
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of DFFB.
• Formulation: In PBS (0.02% sodium azide)
• Gene Accession No.: NP_004393
• Gene Symbols: DFFB
• Immunogen: A synthetic peptide corresponding to amino acids 3-18 of human DFFB.
• Regulatory Status: RUO
• Gene ID (Entrez): 1677
• Content And Storage: Store at 4°C for three months. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: Immunocytochemistry, Western Blot
• Conjugate: Unconjugated
• Dilution: Western Blot (1:500-1:2000) The optimal working dilution should be determined by the end user.
• Gene: DFFB
• Gene Alias: CAD/CPAN/DFF-40/DFF2/DFF40
• Host Species: Rabbit
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid

For Research Use Only