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DFFB Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Catalog No. 89116815 Shop All Abnova Corporation Products
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100 μg
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89-116-815 100 μg
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Catalog No. 89-116-815 Supplier Abnova Corporation Supplier No. PAB13712
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Description

Rabbit polyclonal antibody raised against synthetic peptide of DFFB.

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40kDa (DFFB) and 45kDa (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined. [provided by RefSeq

Sequence: EGLESRFRNKSGYLRYS

Specifications

Antigen DFFB
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of DFFB.
Dilution Western Blot (1:500-1:1000) The optimal working dilution should be determined by the end user.
Formulation In PBS (0.02% sodium azide)
Gene DFFB
Gene Alias CAD/CPAN/DFF-40/DFF2/DFF40
Gene Symbols DFFB
Host Species Rabbit
Immunogen A synthetic peptide corresponding to amino acids 147-164 of human DFFB.
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1677
Test Specificity Recognizes human, mouse, and rat DFF40 / CAD. Detects a band of ∼40 KDa by Western blot. The sequence differs from human DFF40 by two amino acids.
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C.
Form Liquid
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For Research Use Only

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