MilliporeSigma™ Rabbit anti-DNA polymerase beta, Polyclonal,

Catalog No.	Quantity
ABE1408MI	100 μg

Catalog No. ABE1408MI Supplier MilliporeSigma™ Supplier No. ABE1408

Description

Rabbit Polyclonal Antibody

Specifically detects DNA polymerase beta in Human, Mouse, Rat samples, and it is validated for Immunohistochemistry, Western Blotting

DNA polymerase beta (EC 2.7.7.7; UniProt P06746; also known as DNA pol beta, DNA polymerase beta subunit) is encoded by the POLB gene (Gene ID 5423) in human. DNA polymerase beta is involved in DNA recombination and base-excision repair (BER). Upon oxidative DNA damage, Polb translocates to the nucleus, where it associates with AP endonuclease 1 (Apex) to carry out DNA repair. Apex makes a single nick 5′ to an abasic site in double-stranded DNA, Polb then inserts the replacement nucleotide(s). Aberrant POLB overexpression results in an increased rate of spontaneous mutagenesis and a highly mutagenic tolerance phenotype. Thirty percent of all tumors are reported to harbor mutations in the POLB gene.

Specifications

• Antigen: DNA polymerase beta
• Applications: Immunohistochemistry, Western Blot
• Classification: Polyclonal
• Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Accession No.: P06746
• Gene Symbols: POLB
• Host Species: Rabbit
• Immunogen: KLH-conjugated linear peptide corresponding to the C-terminus of human DNA polymerase beta.
• Purification Method: Affinity Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Epigenetics and Nuclear Function
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_002681
• Target Species: Human, Mouse, Rat
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.

For Research Use Only