DUSP1 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-126-523	100 μL

Catalog No. 89-126-523 Supplier Abnova Corporation Supplier No. PAB24852

Description

Rabbit polyclonal antibody raised against synthetic peptide of DUSP1.

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the nonreceptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq

Specifications

• Antigen: DUSP1
• Applications: Immunohistochemistry (PFA fixed), Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of DUSP1.
• Dilution: Western Blot (1:500-1000) Immunohistochemistry (1:50-1:200) The optimal working dilution should be determined by the end user.
• Formulation: In 1X PBS, pH 7.2 (0.05% sodium azide)
• Gene: DUSP1
• Gene Alias: CL100/HVH1/MKP-1/MKP1/PTPN10
• Gene Symbols: DUSP1
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to DUSP1.
• Purification Method: Antigen affinity purification
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1843
• Test Specificity: DUSP1 polyclonal antibody detects endogenous levels of DUSP1 protein.
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only