DUSP4, Rabbit, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of DUSP4.

Supplier:  Abnova Corporation PAB4129

Catalog No. 89-131-285

Description

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq

Specifications

• Antigen: DUSP4
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of DUSP4.
• Formulation: In PBS (0.09% sodium azide)
• Gene Accession No.: NP_001385;Q13115
• Gene Symbols: DUSP4
• Immunogen: A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human DUSP4.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (PFA fixed), Western Blot
• Conjugate: Unconjugated
• Dilution: ELISA (1:1000) Western Blot (1:100-500) Immunohistochemistry (1:50-100) The optimal working dilution should be determined by the end user.
• Gene: DUSP4
• Gene Alias: HVH2/MKP-2/MKP2/TYP
• Host Species: Rabbit
• Purification Method: Protein G purification
• Regulatory Status: RUO
• Gene ID (Entrez): 1846
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

For Research Use Only