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DYRK1A Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No. 89122173 Shop All Abnova Corporation Products
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400 μL
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89-122-173 400 μL
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Catalog No. 89-122-173 Supplier Abnova Corporation Supplier No. PAB2067
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Description

Rabbit polyclonal antibody raised against synthetic peptide of DYRK1A.

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq]

Specifications

Antigen DYRK1A
Applications Immunohistochemistry (PFA fixed), Western Blot
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of DYRK1A.
Dilution Western Blot (1:1000) Immunohistochemistry (1:50-100) The optimal working dilution should be determined by the end user.
Formulation In PBS (0.09% sodium azide)
Gene DYRK1A
Gene Accession No. NP_001387;Q13627
Gene Alias DYRK/DYRK1/HP86/MNB/MNBH
Gene Symbols DYRK1A
Host Species Rabbit
Immunogen A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human DYRK1A.
Purification Method Protein A purification
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1859
Target Species Human
Content And Storage Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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