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Description
This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators. [provided by RefSeq
Specifications
Specifications
| Antigen | ECH1 |
| Applications | ELISA, Immunohistochemistry (PFA fixed), Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Description | Rabbit polyclonal antibody raised against partial recombinant ECH1. |
| Dilution | ELISA (1:10000-1:80000) Western Blot (1:200-1:1000) Immunohistochemistry (1:50-1:200) The optimal working dilution should be determined by the end user. |
| Formulation | In buffer containing 0.02% sodium azide |
| Gene | ECH1 |
| Gene Accession No. | NM_001398 |
| Gene Alias | HPXEL |
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