EDNRB Rabbit anti-Bovine, Dog, Goat, Hamster, Human, Monkey, Mouse, Pig, Rabbit, Rat, Polyclonal Antibody, Abnova
Rabbit polyclonal antibody raised against synthetic peptide of EDNRB.
Manufacturer: Abnova Corporation PAB26265
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Three transcript variants encoding two different isoforms have been found for this gene. While both isoforms bind ET1, they exhibit different responses upon binding, suggesting that they may be functionally distinct. [provided by RefSeq
|Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (8 ug/mL) The optimal working dilution should be determined by the end user.|
|A synthetic peptide corresponding to 19 amino acid at C-terminus of human EDNRB.|
|Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.
|BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Immunohistochemistry (PFA fixed)|
|Rabbit polyclonal antibody raised against synthetic peptide of EDNRB.|
|In PBS (0.09% sodium azide)|
|Bovine, Canine, Goat, Hamster, Human, Monkey, Murine, Porcine, Rabbit, Rat|
For Research Use Only