EDNRB Rabbit anti-Dog, Human, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-127-860	50 μg

Catalog No. 89-127-860 Supplier Abnova Corporation Supplier No. PAB26220

Description

Rabbit polyclonal antibody raised against synthetic peptide of EDNRB.

The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Three transcript variants encoding two different isoforms have been found for this gene. While both isoforms bind ET1, they exhibit different responses upon binding, suggesting that they may be functionally distinct. [provided by RefSeq

Specifications

• Antigen: EDNRB
• Applications: Immunocytochemistry, Immunohistochemistry (PFA fixed), Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of EDNRB.
• Dilution: Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (4-11 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.09% sodium azide)
• Gene: EDNRB
• Gene Accession No.: P24530
• Gene Alias: ABCDS/ETB/ETBR/ETRB/HSCR/HSCR2
• Gene Symbols: EDNRB
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to 19 amino acid at N-terminus of human EDNRB.
• Purification Method: Immunoaffinity chromatography
• Quantity: 50 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1910
• Test Specificity: BLAST analysis of the peptide immunogen showed no homology with other human proteins, except PTPN5 (68%).
• Target Species: Canine, Human
• Content And Storage: Store at 4°C. For long term storage store at -80°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only